Publication: From 3D to 3D with ELAREM™ Matrix

Publication: From 3D to 3D with ELAREM™ Matrix

From 3D to 3D: isolation of MCSs into 3D hPL matrix

The article by Domenik Egger et al. demonstrates the advantages of ELAREM Matrix over other comparable products. The article was published in the Stem Cell Research & Therapy journal and is titled „ From 3D to 3D: isolation of mesenchymal stem/stromal cells into three-dimensional human platelet lysate matrix“.

Isolating MCSs into a 3D environment

The authors developed an approach for the direct isoalation of MSCs from adipose tissue into a 3D environment while avoiding contact to a 2D plastic surface. To avoid this contact, our product ELAREM Matrix was used to isolate the MSCs. Furthermore, the hydrogel serves as adhesion matrix and nutrient supply. This in turn causes a promotion of cell growth and proliferation, which lead to the result that more cells could be harvested from the ELAREM Matrix. Since the scaffold is based on growth factor-rich human Platelet Lysate (hPL), it resembles the in vivo situation optimally.

3D situation is more favourable for physiological cell behaviour

As the 3D cell culture environment enhances a cell behaviour that is more representative of the physiological environment, the isolation into a 3D situation is more favourable than a 2D situation. Furthermore, an avoidance of plastic surfaces is preferable as it contributes to a more natural cell behaviour.

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