Publication: From 3D to 3D with ELAREM™ Matrix
From 3D to 3D: isolation of MCSs into 3D hPL matrix
The article by Domenik Egger et al. demonstrates the advantages of ELAREM™ Matrix over other comparable products. The article was published in the Stem Cell Research & Therapy journal and is titled „ From 3D to 3D: isolation of mesenchymal stem/stromal cells into three-dimensional human platelet lysate matrix“.
Isolating MCSs into a 3D environment
The authors developed an approach for the direct isoalation of MSCs from adipose tissue into a 3D environment while avoiding contact to a 2D plastic surface. To avoid this contact, our product ELAREM™ Matrix was used to isolate the MSCs. Furthermore, the hydrogel serves as adhesion matrix and nutrient supply. This in turn causes a promotion of cell growth and proliferation, which lead to the result that more cells could be harvested from the ELAREM™ Matrix. Since the scaffold is based on growth factor-rich human Platelet Lysate (hPL), it resembles the in vivo situation optimally.
3D situation is more favourable for physiological cell behaviour
As the 3D cell culture environment enhances a cell behaviour that is more representative of the physiological environment, the isolation into a 3D situation is more favourable than a 2D situation. Furthermore, an avoidance of plastic surfaces is preferable as it contributes to a more natural cell behaviour.
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