3D culture model to test chemotherapeutic drugs for treating leukemia In vitro drug testing of chemotherapeutic drugs The aim is to present and establish new drug testing approaches for new leukemic drug developments and testing. Personalized medicine becomes more and more important in order to lead
For all research and cell therapy approaches, cell expansion and thus cell culture media are used and needed. During the last decades (starting in the 1950s) animal serum was the “Gold Standard” for cell expansion because of its high growth factor content and universal use. Cell
Why are Mesenchymal Stem Cells so interesting for industry and clinical research? The properties of Mesenchymal Stem Cells (MSCs) make them capable to be used for a broad application in research fields and the development of cell therapies. One topic is getting more important and looked
Why Human Platelet Lysate outperforms Human Serum for Stem Cell Therapy "Which media should I choose for my application?" - There is no short answer because it depends on the application aim of the cell therapy, the production process and sometimes on the cell types and
Preliminary report phase 1 clinical trial using a xeno-free & GMP compliant protocol with Human Platelet Lysate Madani et al. reported the short term safety of Placenta derived Mesenchymal Stem Cells (PLMSCs) transplanted in 4 children (Type 1 Diabetes Mellitus patients (T1DM)). The manufacturing of PLMSCs to the
"In vitro characterisation of 3D printed Platelet Lysate-based bioink for potential application in skin tissue engineering" In a lately published study Daikuara et al. developed an extrusion-based bio-ink consisting of Human Platelet Lysate (PL) and gelatin methacryloyl (GelMA). The bio-ink should be used for the 3D
World Earth Day 2021: Environmental Impact of HPL vs. FBS What do HPL and FBS have to do with the Earth Day 2021? The Earth Day raises awareness and educates people about a more sustainable living. For us, this means we educate about a more sustainable cell
Vero cells are used in the development of Covid-19 vaccines Vero cells are used a lot in research and industry. Time to have a closer look at this cell line: Vero cells are continuous cell lines that was derived from the kidney of an African green monkey
Today is world cancer day A great opportunity to raise awareness for cancer patients and survivors as well as for cancer research and therapies. Cancer is one of the most serious diseases causing almost one in six deaths globally, which is estimated to equal 9.6 million
Animal experiments are one of the most discussed topics in research and in our society. We neither want to condemn animal experiments nor do we want to trivialize this topic. What we want is to raise awareness and open a fact-based discussion about it. Animal experiments are
Fatal disadvantages of FBS shown The essay by Toni Lindl and Gerhard Gstraunthaler demonstrates the fatal disadvantages of Fetal Bovine Serum (FBS). The article published in the German scientific magazine 'Laborjournal' proposes a contemporary cell culture solution: Human Platelet Lysate (hPL). High reproducibility of trial results achieved
Interview with our colleague Ute Steinbusch in the issue 3/2016 of the magazine 'Laborjournal' (Article only available in German) Textauszug: "Die Zahl serumfreier Alternativen zum FBS steigt. Ein Start-up aus Aachen beispielsweise bietet humanes Blutplättchenlysat (hPL) als Wachstumsmedium an - auf Wunsch sogar dreidimensional. Ein Gespräch über Zweitverwertung und
