Enhanced performance of IFP-MSCs with our hPL

hPL enhanced performance for IFP-MSCs

Enhanced performance of IFP-MSCs with our hPL

The study performed with human Platelet Lysate (hPL) at the University of Miami showed an enhanced performance of manufactured IFP – MSCs under regulatory compliant conditions.

The aim of the study was to proof the hypothesis: IFP-MSCs manufactured under these conditions do not need “ex-vivo priming to acquire a CD10-rich phenotype efficiently degrading SP and reversing synovitis and IFP fibrosis.”

IFP: Infrapatellar Fat Pad, this pad in the knee plays a role in modulating inflammatory responses

“hPL […] can effectively replace FBS to induce specific therapeutic attributes in IFP-MSCs”

The tests of processing human IFP-MSCs were performed with FBS, our human platelet lysate (hPL) ELAREM™ Perform (former named PL Solution) and chemically reinforced medium (Ch-R).

The results showed that in comparison to FBS, hPL and Ch-R enhanced the cell performance. IFP-MSCs manufactured with hPL showed enhanced:

  • proliferation
  • differentiation
  • immunomodulatory profiles
  • transcriptionalprofiles
  • secretory profiles

SP degradation is more efficient with hPL

Why the SP degradation is a fundamental point in the research:

SP is a Substance which is a neurotransmitter. This neurotransmitter is secreted within structures associated with inflammations.

Why these results are important and relevant for the clinic

The manufacturing of IFP-MSCs under these conditions has an influence on the design of clinical protocols. This might lead to reviewed treating conditions involving synovitis and IFP fibrosis.

  • accelerated time from preclinic to clinical phases
  • higher efficacy at lower MSC numbers than currently needed
  • avoidance of cell priming for efficient results

“CD10/Neprilysin Enrichment in Infrapatellar Fat Pad–Derived Mesenchymal Stem Cells Under Regulatory-Compliant Conditions: Implications for Efficient Synovitis and Fat Pad Fibrosis Reversal” ( American Journal of Sports Medicine, May 2020)

You find the Study here

More Publications about hPL on our Website

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